Two-Step Mechanism of Homogeneous Nucleation of Sickle Cell Hemoglobin Polymers
نویسندگان
چکیده
منابع مشابه
Mechanisms of homogeneous nucleation of polymers of sickle cell anemia hemoglobin in deoxy state.
The primary pathogenic event of sickle cell anemia is the polymerization of the mutant hemoglobin (Hb) S within the red blood cells, occurring when HbS is in deoxy state in the venous circulation. Polymerization is known to start with nucleation of individual polymer fibers, followed by growth and branching via secondary nucleation, yet the mechanisms of nucleation of the primary fibers have ne...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2007
ISSN: 0006-3495
DOI: 10.1529/biophysj.106.103705